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Murphy and George Minot for discovery of an effective treatment for pernicious anemia using liver concentrate, later found to contain a large amount of vitamin B 12

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These can include: learning problems or intellectual disabilities delays in walking and motor skills abnormal involuntary movements ( dystonia and chorea ) rigid muscle tone, called spasticity poor growth with short stature skin rashes and infections osteoporosis enlarged liver kidney disease or failure vision loss due to problems with the nerves in the eye Without treatment, brain and nerve damage can occur