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Administration routes tested included both intravenous injection and oral formulations delivered as capsules or tablets

A 2025 systematic review in the American Journal of Sports Medicine confirmed preclinical support across tendon, ligament, muscle, and bone repair models while explicitly noting the absence of human clinical trial data (DOI: 10.1177/15563316251355551)
The headline belongs at the top, not buried under the neurogenesis story: NSI-189's Phase 2 trial failed its primary endpoint for depression, and clinical development was discontinued

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Shibata Y., Tsukazaki T., Hirata K., Xin C., Yamaguchi A

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