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The theoretical framework for synergy rests on well-established principles of systems biology

Notably, the authors highlighted significant methodological limitations across the included studies, such as small sample sizes, short follow-up durations, and high heterogeneity in baseline selenium status, dosage regimens, and patient populations

Colloid Solutions: While less common in routine urgent care, colloids like albumin may be used in special circumstances, such as severe dehydration with low blood protein levels, or when rapid expansion of blood volume is needed

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10.3389/fcimb.2021.822882 154
