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Functional impairment in aged MuSCs is accompanied by a shift in transcriptional programs, with increased expression of activation markers such as FOS , JUN , and EGR1 and reduced expression of quiescence-associated genes including CALCR and FOXO3

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A prototypical autoimmune disease characterized by B cell hyperactivity, autoantibody production and a range of symptoms that can include vasculitis, arthritis, glomerulonephritis, fever and neurological abnormalities

FACS analysis of yeast showed a gradual increase in biotinylation efficiency over the course of evolution, with LaccID being fourfold more active than the original template LacAnc100 (Fig