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doi: 10.1158/1078-0432.CCR-14-1758

E2 plays a significant and complex role in regulating melanin production and skin pigmentation [36]

Therefore, NFE2L2 serves a crucial role in the transcriptional regulation of ferroptosis, primarily via the activation of genes that counteract cellular damage (61)

For prescribers, the restriction created an immediate clinical gap

Genome Research
