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It is unknown whether tirzepatide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of tirzepatide -induced rodent thyroid C-cell tumors has not been determined

This leads to the development of hypoxia (decreased oxygen levels) in intestinal epithelial cells and activation of hypoxia-inducible factor alpha (HIF-1) (Wu et al., 2020)

But even accounting for reporting bias, the signal is significant

Studies in mouse models with heterozygous GPx deficiency reveal heightened susceptibility to oxidant stress, emphasizing its protective function in heart tissues

N.D., Not detected