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After intratracheal instillation in male Wistar rats, nickel oxide (Nio) NPs activated the NF-B pathway by upregulation of mRNA and protein expression of NF-B, an inhibitor of B kinase- and nuclear factor-inducing kinase, partially causing pulmonary damage ( 2 NPs induced the lung alveolar epithelial cell apoptosis by ROS-regulated PI3K/AKT-mediated mitochondria- and ER stress-dependent signaling pathways, leading to lung injury (Lee et al., 2020)

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Spatial patterns and age-related changes of the collagen crimp in the human cornea and sclera

A 2021 study published in Biomedicines it demonstrated that BPC-157 significantly improved tendon healing in rats by promoting angiogenesis and collagen synthesis, leading to faster functional recovery (Sikiric et al., 2021)