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Nutrients 13 (10), 3637

Figure 8 illustrates how a single exposure vs constant infusion of a wide range of doxorubicin concentrations (050 M) affects cytosolic GSH concentration

Although it is beyond the scope of this study to identify the mechanisms by which PDF leads to the activity-dependent (TTX-sensitive) upregulation of CLK/CYC-transcription, we speculate that Ca 2+ influx downstream of PDF/PDFR signalling leads to an upregulation of clock gene transcription

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These methods are broadly applicable, and the construction and parameterisation of a variety of biochemical and morphodynamic models will be improved with better data