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The multicentre, randomized, double-blind, placebo-controlled ALADIN III trial demonstrated significant improvement in the Neuropathy Impairment Score (NIS) in patients who received -lipoic acid but no significant improvement in the Total Symptom Score (TSS) 176
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Next, we had a small sample size ( n = 14) in the DLPFC which made it difficult to make comparisons between regions (ACC vs
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Thus, MRP1 has a chemoprotective role in multiple tissues (4, 1618)
