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B-12 is a water-soluble vitamin

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Although motor symptom improvement can still be achieved in PD patients, higher programming voltages are required, and more adverse reactions are observed

In Vgat-ChR2 and Vgat-IRES-cre transgenic mice, we found for the first time that tesofensine inhibited a subset of LH GABAergic neurons, reducing their ability to promote feeding behavior, and chemogenetically silencing them enhanced tesofensines food-suppressing effects

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