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In steroidogenic tissues, such as the placenta, ovaries, testes, and adrenal cortex, it is used to hydroxylate intermediates in the conversion of cholesterol to steroid hormones, a process that makes these hydrophobic compounds more water soluble

Enhanced expression of GLS2 by p53 activation or by ectopic overexpression promoted glutaminolysis leading to increases in cellular glutamate and GSH levels (36)

The Lavis group made a seminal discovery that substituting the dialkylamino group with an azetidine group is a general method to significantly improve quantum yields of fluorophores 17

Of note, since the gut-skin microbiome axis can contribute to cutaneous homeostasis and pathogenesis, the use of fecal microbiota transplantation represents a potential innovative strategy to cure skin inflammatory conditions [83]