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Persistent very high levels (for example, sustained above 3 SDS in clinical context) may need clinician review, dose adjustment, or stopping

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These strict criteria ensure that only medically appropriate candidates benefit from our Cellular Immunotherapies for Myelodysplastic Syndromes (MDS) , preserving both therapeutic success and safety [24-31]

If lifestyle measures are insufficient , your GP may recommend: Osmotic laxatives (such as macrogol) are often recommended as first-line treatment for chronic constipation Bulk-forming laxatives (such as ispaghula husk) may be suitable when stools are small and hard, particularly with IBS-like symptoms Stimulant laxatives (such as senna or bisacodyl) for short-term use in resistant cases According to NICE Clinical Knowledge Summaries , laxatives should be used appropriately and reviewed regularly