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This can show up as symptoms such as delayed growth and development (failure to thrive), regression in neuromotor skills (such as losing the ability to roll over or grasp objects), failure to maintain eye contact (even in an infant who previous could do so), general muscle weakness, lethargy, excessive sleepiness, feeding difficulties, and even brain shrinkage

According to the original developer documentation and supporting preclinical work, the substitution was engineered to eliminate protein biosynthesis stimulation while retaining lipolytic activity, removing the muscle-growth signaling associated with full-length HGH