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doi: 10.1038/s41598-018-37448-z 75 ZhuJJiaEZhouYXuJFengZWangH

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Leave the patch on for 6-8 hours: For maximum effectiveness, leave the patch on for several hours or overnight to allow the copper peptides to penetrate the skin and provide long-lasting relief

Coffee enema with PEG group A split dose of PEG (1 L of the total 2-L dose) was administered before and after the coffee enema

Zhang, Z., Chen, D., Lu, X., Zhao, R., Chen, Z., Li, M., et al., Front