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The question arises whether humans suffer similar consequences at the molecular level and whether these molecular consequences lead to chronic illness and symptoms

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Metabolic signature of the aging eye in mice

This is curious because of the general assumption that nuclear IGF-1R cannot be accessed by antibodies - crossing the membrane is challenging and import to the nucleus of an antibody bound to IGF-1R is unlikely because of the size of the complex

Technologies such as spatial transcriptomics, proteogenomics, PDOs, and AI-based multi-omics are enhancing the understanding and targeting of mitochondrial metabolism in CRC