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Cellular iron homeostasis is primarily regulated by the iron-sensing ubiquitin ligase, F-box and leucine-rich repeat protein 5 (FBXL5), and RNA-binding protein, iron regulatory protein 2 (IRP2, also known as IREB2)

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GSEA also showed that the upregulated genes in 6KR/KO versus WT/KO cells were enriched in genes downregulated in MED1 -KO cells versus MED1 WT cells, while the downregulated genes in 6KR/KO versus WT/KO cells were enriched in genes upregulated in MED1 -KO versus MED1 WT cells (Fig

There was no purulent drainage, but redness persisted at the site