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Then, free choline is transported back by CHTs for further ACh synthesis ( 1.2 Choline demands throughout the lifespan and choline supplementation Choline is an essential nutrient throughout life, with particularly high demands during periods of rapid cell proliferation, such as pregnancy

PMID: 34959912

Nibuya M, Morinobu S, Duman RS

Value of 11C-choline PET/CT for lung cancer diagnosis and the relation between choline metabolism and proliferation of cancer cells

Clinical and preclinical studies have shown that lipid over supply causes or worsens insulin resistance via multiple mechanisms including the accumulation of intracellular lipids in various tissues