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To assess the different clinical cisplatin treatment regimens, in vivo rat models of acute and chronic cisplatin administration were used

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Methods Animal husbandry Experiments were performed either on C57BL/6 (B6) animals acquired from the Institute for Basic Science Animal Facility (larf.ibs.re.kr) or on AD mouse model mouse APPswe/PSEN1dE9 (APP/PS1) mice of B6C3 hybrid background (RRID: MMRRC_034829-JAX), originated from Jackson Laboratory (USA, stock number 004462) and maintained as hemizygotes by crossing transgene-carrying mice with B6C3 F1 animals