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Nonetheless, labeling patterns for multiple TCA cycle intermediates (including aspartate, malate, fumarate, citrate, and -ketoglutarate) mirrored those observed in the MEC-1/N M cells, with higher glutamine-derived incorporation in CLL/N M compared to CLL/N WT (Supplementary Fig

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Novel compounds and therapeutic approaches exhibit restricted clinical efficacy attributable to factors such as short half-life, in vivo stability, and challenges associated with blood-brain barrier penetration, among others (177)

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Di Martino MT, Riillo C, Scionti F, Grillone K, Poler N, Caracciolo D, et al

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