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This process involves the repositioning or restructuring of nucleosomes, thereby changing the accessibility of DNA to transcription factors and regulatory proteins, which in turn affects the expression of NRF2 target genes

J Basic Clin Physiol Pharmacol 26(5):491499 Ahmadian R, Rahimi R, Bahramsoltani R (2020) Kaempferol: an encouraging flavonoid for COVID-19

Despite promising results from preclinical investigations, clinical studies often face issues related to poor bioavailability, inconsistent dosing, and methodological variability

In addition to the primary performance and health "markers" measured by the researchers, secondary markers also increased in the combo group: O2 pulse, total haemoglobin and myoglobin in skeletal muscle tissue, and BAP (a test designed to assess the Biological Antioxidant Potential of blood plasma)