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Nelson DB, Mitchell KG, Weston BR, Betancourt S, Maru D, Rice DC, Mehran RJ, Sepesi B, Antonoff MB , Walsh GL, Swisher SG, Roth JA, Vaporciyan AA, Blum M, Hofstetter WL

N -hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

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Release 329, 894906

Additionally, tazemetostat, a zeste homolog 2 (EZH2) inhibitor that promotes cell differentiation, has been approved for the treatment of follicular lymphoma [8]