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In macrophage cells, -KG produced via glutaminolysis promotes M2 activation via Jmjd3-dependent metabolic and epigenetic reprogramming 108

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Highlights Circadian rhythm disruptions contribute to kidney and eye disease pathogenesis

Despite some reports on the similarities between senescence and eryptosis at the morphological level [67], intracellular Ca 2+ elevation [74], Ca 2+ -driven activation of Gardos channels [70], PS exposure [76], or ROS contribution [71], senescence of erythrocytes cannot be considered an RCD of these cells and should be clearly distinguished from eryptosis

Collectively, these findings suggest that irisin exerts neuroprotective effects by inhibiting the function of HIF-1 through SIRT1-mediated deacetylation