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The limited availability of free CoA leads to the arrest of the beta-oxidation process and to the accumulation of harmful long-chain acylCoA and acylcarnitines in the mitochondria

Furthermore, ETC deficiencies are noted in the subunits that are encoded by the mitochondrial DNA, specifically in the ETC Complex III (Poling et al., 2006)

Perhaps LAC may be the next potentially effective and tolerable treatment with new mechanisms for patients with depression, especially for elderly and female patients, as well as patients with concomitant diseases who are vulnerable to the adverse effects of antidepressants