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Furin is ubiquitously expressed

However, from the available peptides that reached the level of clinical trials, the presented results are limited

AndreassenOADedeogluAFriedlichAFerranteKLHughesDSzaboCet al

To dig deeper into this phenomenon the team examined the citation network of a retracted Nature paper

demonstrated that PET NPs (size and dose not reported) can skew the immune balance towards a pro-inflammatory phenotype (shift to Th1/Th17), disrupt immune regulation by decreasing Treg cells and IL-2, and potentially contribute to the development of immune-mediated disorders through increased secretion of pro-inflammatory cytokines and reduced regulatory signalling [87]