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As a cysteine donor in reduced GSH biosynthesis, NAC amplifies the intracellular antioxidative machinery, curtails lipid peroxidation, and mitigates ferroptotic pathways ( 4.2.2 Interruption of lipid peroxidation inhibits ferroptosis Lip-1 plays a pivotal role in modulating ferroptotic processes by effectively neutralizing lipid peroxides and free radicals ( 4.2.3 Chelate iron ions to inhibit ferroptosis Given that iron accumulation stands as the principal pathological event of ferroptosis, iron chelators such as DFO and DFP, capable of lowering intracellular iron content, emerge as strategic inhibitors of the genesis and progression of ferroptosis ( in vitro experiments, where pancreatic islet cells faced the crucible of erastin and RSL3 treatment for 24 h, a stark proliferation of cell death prevailed

Exogenous expression of wild-type LSS prevented intracellular protein aggregation, which was caused by various crystallin mutations

Puri N, Mojamdar M, Ramaiah A

Conclusion GSH is one of the most abundant antioxidants that helps fight and prevent damage caused by OS (Kwon et al., 2019), and is thought to play an important role in both aging and age-related neurodegenerative diseases (Dix et al., 2017)