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The combination exceeds the mathematical sum of its parts, suggesting synergistic rather than merely additive effects

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The dependence of tyrosine hydroxylase on BH 4 necessitates the coupling to the action of dihydropteridine reductase (encoded by the QDPR gene: quinoid dihydropteridine reductase) as is the situation for tryptophan hydroxylase (see below) and phenylalanine hydroxylase

Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1/VEGF signaling pathway in human bladder cancer cells

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