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The importance of clinical outcomes in evaluating the effectiveness of these interventions, particularly in organ transplantation, is underscored by the increased risk of morbidity and mortality associated with I/R injury

Now, this is a controversial point

WADA;2025

According to the FDA Adverse Event Reporting System (FAERS) database, from October 2012 through September 2021, 489 adverse events associated with kratom (i.e., mitragynine) have been reported, including 244 deaths (Li et al., 2023)

Why It Matters: Food in the digestive system competes for absorption, reduces bioavailability, and may bind to the compound, limiting effectiveness