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Although these findings provide significant mechanistic insight, they primarily originated from animal or in vitro studies, and their translational relevance to long-term human health remains uncertain

IP6K3, located near the major histocompatibility complex, has previously been linked to other autoimmune diseases such as Graves disease and rheumatoid arthritis, indicating its potential role in the development of autoimmunity and HT [20]

The fundamental concept has been extensively utilized as a powerful instrument for separating and purifying a wide range of macromolecules used in biology