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Some biology approaches including total RNA-sequencing (RNA-seq), single cell RNA-seq, chromatin-immunoprecipitation-sequencing (ChIP-seq), and DNA methylation profiling can help us to further explore the epigenetic regulation with ferroptosis (Xu et al., 2018)

Since the amount and quality of leptin receptors in the hypothalamus appears to be normal in the majority of obese humans (as judged from leptin-mRNA studies), [123] it is likely that the leptin resistance in these individuals is due to a post leptin-receptor deficit, similar to the post-insulin receptor defect seen in type 2 diabetes

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Nanoparticleliver interactions: cellular uptake and hepatobiliary elimination

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