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On day 21, no apparent tumor growth was observed in P-CyPt-treated mice, however, the tumor volume significantly grew ~21.2-, ~15.8- and 13.0-fold in PBS-, CDDP- and Pt IV NPs-treated mice, respectively (Fig

Glutathione plays a central role as antioxidant defense, as well as in the regulation of pathways involved in cellular homeostasis, not only as a detoxifier of endogenous and exogenous compounds, but also through its participation in processes related to cell proliferation, apoptosis, gene expression, regulation of the immune system, and metabolism of cell compounds, among others

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