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Serine can be converted to glycine or it can also be converted to hydroxypyruvate, which can then be converted to glyoxylate with the help of the GRHPR enzyme
Additionally, overexpression of thioredoxin (Trx) has been demonstrated to inhibit the progression of insulin resistance in both type 1 and type 2 diabetes in vivo (Yamamoto et al., 2008)
A nationwide prospective study
