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On the other hand, clinical data suggest a high analgesic efficacy after intra-articular administration: as many as 87.5% of patients with knee pain experienced improvement following BPC-157 treatment, both as monotherapy and in combination with thymosin beta 4 (TB4) [201,202]

*Correspondence: Yongqing Hou [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Animal Nutrition and Metabolism, a section of the journal Frontiers in Veterinary Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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In addition, the docking simulation result showed that genistein interacted with the core cavity of the ER active site (Fig