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Additionally, both the antidepressant esketamine and the dextromethorphan-bupropion combination, approved by the US FDA, function through a shared mechanism that involves the activation of glutamatergic signaling in the prefrontal cortex [9-11]

Phosphorylation and dephosphorylation events are mediated by kinases and phosphatases, respectively, creating a constant equilibrium that allows for rapid and reversible changes in protein function, activity, and interactions

It has also been linked with shifts in inflammatory markers in preclinical work

expecting subtle shifts allows recognition of genuine changes