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Its known that 22 splice variants of hTERT exist (Plyasova and Zhdanov 2021) however, only the full-length variant codes for the fully active telomerase enzyme and some variants can act in a dominant negative way to inhibit telomerase activity

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In 2012, Huang et al (85) demonstrated that antiangiogenic treatment influences the effectiveness of immunotherapy by the modulatory activity of antiangiogenic agents on tumor microenvironment