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In SPMS, characterized by steady deterioration without acute attacks, treatment strategies often involve continuing or altering DMT used during the earlier RRMS phase, such as interferon beta, or considering immune-modulating agents, such as methotrexate, cyclophosphamide, or glucocorticoid pulses [142, 143]

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TB-500, on the other hand, has been linked to corneal wound research, where it appears to influence inflammatory signaling pathways and may reduce apoptosis in epithelial cells

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