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doi: 10.1001/jamadermatol.2019.2855

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Arch Toxicol 74:473479 Asimakopoulou A, Panopoulos P, Chasapis CT, Coletta C, Zhou Z, Cirino G, Giannis A, Szabo C, Spyroulias GA, Papapetropoulos A (2013) Selectivity of commonly used pharmacological inhibitors for cystathionine synthase (CBS) and cystathionine lyase (CSE)

When used together, MTX and the added drugs can attack joint inflammation from multiple, complementary angles, producing a synergistic effect that is more powerful than either drug alone (Friedman & Cronstein, 2019)