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It was first isolated in 1974 from the cerebral venous blood of rabbits in a sleep state by Monnier and colleagues, making it one of the earlier identified endogenous neuropeptides associated with sleep-wake cycle regulation research

Instead, it uses the amount of vitamin C it needs and excretes the rest

The exogenous addition of substrates for CSE (Cys), MPST (3MP) or SQR (H 2 S) lowered endogenous radical load, in line with the notion that enzymatically generated S 0 species contribute to radical scavenging (Fig