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Synthetic form: While DSIP occurs naturally in small amounts, the versions used in research and supplementation are synthetically produced to mimic the bodys own peptide

[28] The two primary metabolic routes that convert dopamine into HVA are: [29] Dopamine DOPAL DOPAC HVA catalyzed by MAO, ALDH, and COMT respectively Dopamine 3-Methoxytyramine HVA catalyzed by COMT and MAO+ALDH respectively In clinical research on schizophrenia, measurements of homovanillic acid in plasma have been used to estimate levels of dopamine activity in the brain

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[DOI] [PubMed] [Google Scholar] 55.Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS