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Mammalian sirtuins: biological insights and disease relevance
Underlying this metabolic reprogramming is the abnormal activation of core transcription factors such as HIF-1 and NF-B, which regulate the expression of genes related to glycolysis, amino acid catabolism, and fatty acid oxidation, respectively ( Table 1 Overview of relevant metabolites and their normal functions in COPD
10.1016/j.redox.2021.102195 156 PorschF.MallatZ.BinderC
MicroRNA-218 (miR-218) released from dying motor neurons in ALS can directly modify astrocytes into disease-associated phenotypes (Hoye et al., 2018)
doi: 10.3390/app11209414
