glutathione mitochondrial dysfunction Unearthing the secrets of ROS and in bioenergetics: Trends in Biochemical Sciences Genetic defect in glutathione synthesis

Natural history of muscle cramps in amyotrophic lateral sclerosis

A simplified form of the reaction follows: Equation 2: X-Z + GS- GS-X + Z- Pumps that recognize the glutathione conjugated with a xenobiotic (Figure 21) (GS-X) have been described in animal plasmamembranes and plant tonoplast membranes

Wang et al., 2020)

Dusek P, Roos PM, Litwin T et al (2015) (2015) The neurotoxicity of iron, copper and manganese in Parkinsons and Wilsons diseases

Such alterations can further aggravate key pathological features in the 5xFAD mouse model including increased deposition of A plaques and deficits in learning and memory