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72 A KD is usually defined as an isocaloric diet low enough in CHO and high enough in fat to induce significant elevations (0.5 mmol/l in humans) of the ketone bodies (KBs) -hydroxybutyrate and acetoacetate (termed ketosis)
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l-2HG production was achieved by glutarate hydroxylase extending lysine biosynthesis in a six-step cascade, in which only the last committed step catalyzed by oxygen-dependent glutarate hydroxylase requires oxygen
