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A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction

glutathione synthetase (GSS) then forms the tripeptide by linking glycine to -glutamylcysteine 2,3

Wearden AJ, Morriss RK, Mullis R, et al

Furthermore, knockdown of Suv39h1/2 in adult mouse dentate gyrus impaired neurogenesis, indicating that Suv39h1/2-mediated H3K9me3 is important for adult hippocampal neurogenesis

Significantly, although methionine is identified as an important factor of nutritional epigenomics for maintaining T cell function, the tumor-derived or exogenous SAM metabolite also reprograms chromatin accessibilities of CD8 + T cells, leading to T cell dysfunction (50)