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ER stress is activated when proteostasis is broken with an accumulation of misfolded and unfolded proteins in the ER

In contrast to the frontal association cortex, neurons in the auditory cortex, which is involved in fear memory recall, respond to fear conditioning by increased spinogenesis, and fear extinction favors the elimination of those new spines (Lai et al., 2018)

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This uncertainty stacks on top of the biological uncertainty: you may not know exactly what the molecule does, and you may not know exactly what you have

Devices simply redirect and amplify it