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This activation converts pro-interleukin-1 (pro-IL-1) and pro-interleukin-18 (pro-IL-18) into their active forms, which are subsequently released extracellularly, initiating sustained inflammation that disrupts neural circuits and promotes both seizures and depressive behaviors

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Stress-related dysbiosis is characterized by a reduction in Bifidobacterium and an increase in Firmicutes, which are linked to mood disorders, chronic inflammation, and adverse reproductive outcomes via immuneendocrine disruption [29,30]

Additionally, quercetin reduced the nuclear content of GSH and induced a pro-oxidant response that was not observed in plant cells (Sahu and Gray Reference Sahu and Gray1996)

also focused on the involvement of miR-424 and miR-631 in the regulation of tumor resistance and sensitivity