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The G6PD A- variant is a Class III variant and is more common in people of African descent

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Hence, plasma betaine levels were positively correlated with insulin sensitivity [87]

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In addition, SLC7A11 inhibitors such as erastin, which induce ferroptosis, significantly improve oxaliplatin sensitivity when used in combination with FOLFOX, highlighting the potential of metabolic interventions to reverse chemoresistance [159]

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