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For instance, the Large Tumor Suppressor Homolog 1 (LATS1) contains two PPxY motifs, and the latter PPPY 559 motif in LATS1 is responsible for binding to both WW domains of YAP1, leading to the phosphorylation of YAP and regulation of its subcellular localization [42]

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As an example of the tightly interconnected lesions that multiorgan failure causes, there may be a wide interconnected therapy effect in the recovery of the occlusion/occlusion-like syndrome [18,19,20,21,22,23,24,25,26,27,28,29,30]