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Depending upon the amount of kavalactones contained in the resin, the rootstock shows different color, varying from white to dark yellow (2,5,6)

One of them, (R)-PFI-2, inhibits the methyltransferase activity of Set7/9 at nanomolar concentrations and does not exhibit toxicity at an effective concentration in human cells 179 , 180

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Similarly, the C-X3-C Motif Chemokine Ligand 1/C-X3-C Motif Chemokine Receptor 1 (CX3CL1/CX3CR1) pathway, which is unique in the CNS, has been implied to possess divergent functions