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Description
IGF-DES is a naturally occurring splice variant that has been artificially optimized for therapeutic use
In addition, the compounds were identified by comparison with analytical reference standards when available
Furthermore, E362 is nearby C326 and likely keeps the cysteine reduced for covalent attack of the aldehyde, as evidenced by the reduced activity upon its substitution (E362A)
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10.1136/jitc-2022-006365 J Immunother Cancer
