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As mentioned in the Introduction, both lowered SpO2 and increased body temperature are part of the immune-inflammatory response, predict critical illness and death, and are manifestations of the infectious-immune-inflammatory core of acute COVID-19 [94]

Such effects may be of physiological significance, especially if localized to specific cells in certain conditions, eg, during plant responses to pathogens

It may point to liver disease, blood disorders or an underlying cancer that has not yet been detected

25 Over 50% of cutaneous melanomas harbor BRAF mutation, which can induce a robust increase of its kinase activity and constitutive enhancement of downstream MEK-ERK signaling cascade

doi: 10.3390/nu11030647