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Cagrilintide is a long-acting amylin analogue (acylated 37-amino-acid peptide, 3924 Da) studied for appetite control and weight reduction

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This property is important because many peptide-based molecules have been known for their low stability [33], hence frequent administrations are usually required to ensure the efficacy of the drug, especially when delivered orally

Our experience shows that many researchers opt for split-dosing protocols, administering the compound two or three times per day to minimize large peaks and troughs in plasma levels

Li, D., Yang, Y., Li, R., Huang, L., Wang, Z., Deng, Q., & Dong, S